Our Mission!

 

 Develop a Vaccine and Therapeutic against Hepatitis E

Hepatitis E (HEV)

Unmet Medical Need

20 millions infections annually

3,4 millions symptomatic cases / annum
(chronic & acute)

70.000 deaths

3.000 stillbirths / annum

up to 25% mortality rate in pregnant women, and poor fetal outcomes

 

Investment?

Investment Opportunity

Right now we are out there to look for potential Partners! If you are interested feel free to contact us at any time!

WE SEEK CAPITAL
  • to secure the preclinical development
  • to prepare clinical development of our lead products
  • to complete at least one Phase 1 trial
 
WE OFFER AN ATTRACTIVE OPPORTUNITY
  • value-driving milestones will increase our valuation significantly in the next 6 years
  • trade sale or license deals are likely and attractive exit scenarios

Lady Mary Wortley Montagu

She defied convention most memorably with her pioneering of a smallpox inoculation, a course of action unparalleled in medical advance up to that point. Lady Mary's own brother had died of smallpox and her own famous beauty had been marred by a bout with the disease in 1715.

In 1717, she went to live in Turkey with her husband, the British ambassador to that country, and stayed for two years. In the Ottoman Empire, she visited the women in their segregated zenanas, learning Turkish, making friends and learning about Turkish customs. There she witnessed the practice of inoculation against smallpox—variolation—which she called engrafting, and wrote home about it. Variolation used live smallpox virus in the liquid taken from a smallpox blister in a mild case of the disease and carried in a nutshell. Lady Mary was eager to spare her children, and had her son inoculated while in Turkey. On her return to London, she enthusiastically promoted the procedure, but encountered a great deal of resistance from the medical establishment, because it was an "Oriental" process.

In later years, Edward Jenner, who was 13 years old when Lady Mary died, developed the much safer technique of vaccination using cowpox instead of smallpox. As vaccination gained acceptance, variolation gradually fell out of favour.

Hepatitis

Hepatitis is a general term meaning inflammation of the liver and can be caused by a variety of different viruses such as hepatitis A, B, C, D and E. Since the presentation of icterus or jaundice is a characteristic symptom of liver disease, a specific diagnosis of infection by a hepatitis virus can only be made by testing patients' sera for the presence of specific viral antigens, nucleic acid sequences and/or anti-viral antibodies.
 
Hepatitis E was not recognized as a significant human disease until 1980, when specific tests for antibody against hepatitis A were first applied to the study of epidemic waterborne hepatitis in India. The results showed that the epidemics were not due to hepatitis A; indeed, very few epidemics of waterborne disease in developing countries of Asia and Africa have been linked to hepatitis A.
 
The first experimental evidence for the existence of an additional waterborne hepatitis agent was reported in 1983[1]. This form of non-A, non-B hepatitis came to be known as Enterically Transmitted non-A non-B hepatitis (ET-NANB), Epidemic non-A non-B hepatitis (ENANB), or faecal-oral non-A non-B hepatitis, and the agent of this disease was subsequently found to be the major cause of sporadic hepatitis cases in regions where the epidemic disease was known to appear.
 
[1] Balayan MS, et al. (1983) Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology 20:23-31.

From the Past to the Future

Lady Montagu was a true pioneer of her time. Our main goal at MVT-Biotechnology is to develop a vaccine and therapeutic for Hepatitis E.

VACCINE

  • Well established vaccine technology
  • Start Clinical PH1 in less than 6 years

VACCINE UPTAKE

  • Travellers and populations in endemic regions
  • Young women, (pre) childbearing age in developed & developing countries
  • Young men/adolescents
  • At-risk groups: animal husbandry, food-chain workers, students

THERAPEUTIC

  • Reduce mortality and morbidity
  • Faster resolution and return-to-work
  • Therapeutic for at-risk groups (immunocompromised, transplant patients etc)

Montegu Vaccine & Therapeutics

to prevent and cure